But if you’re not sure how to cut a pomegranate, getting it open and harvesting the seeds isn’t exactly intuitive. When done without strategy, seeding a pomegranate can be messy, resulting in seeds that have been cut, bruised, or simply lost to the process. Cut the pomegranate into quarters—then peel with your handsAccording to Khan, your hands are your best tool for opening and eating pomegranates. Here’s her method: Use a sharp knife to cut the pomegranate in half, then into quarters. Consider this your ultimate pomegranate seeding setup.